27th International Conference on Chelation -
A Landmark on Chelation Science and Medicine

6th International Conference on Oncology and Anticancer Research
9th International Conference RAHMS: Recent Advances in
Health and Medical Sciences
Paphos, Cyprus: 22-27th June, 2018




1998 - 2018




www.visitcyprus.com



www.pafos2017.eu
THE PRESIDENT OF THE LOCAL ORGANISING AND SCIENTIFIC COMMITTEE OF THE CONFERENCES

Welcome to Paphos, Cyprus, EU the host town of the 27th ICOC, 9th RAHMS and 6th ICOAR international conferences for 2018. Paphos history spans through thousands of years and has many natural, cultural and ancient attractions. It has been known in ancient times as the birthplace of Aphrodite or Venous, the goddess of love, who was born from the foam of the sea waves. The participants of the conference will have the opportunity to visit the ancient sites, museums and also many other areas which are of cultural and natural sightseeing interest.

The venue of the conference is situated on a beach area near the centre of Paphos and a walking distance from shops and restaurants. As in previous conferences the tranquillity of the venue and the excellent Cypriot cuisine and hospitality will be stimulating for a successful conference in relaxing surroundings.

New developments on the scientific front are related to efforts for the prevention and treatment of endemic and other diseases of Cyprus including Thalassaemia and Friedreich Ataxia. Cyprus is well known for the high incidence of inherited diseases. It is estimated that one in six Cypriots is a carrier of thalassaemia and one in a thousand Cypriots is a thalassaemia patient. In the last four decades preventative measures and educational efforts have diminished the birth of thalassaemia children in Cyprus. Substantial improvement in the quality of life and a sharp decrease in the mortality and morbidity of existing thalassaemia patients have been achieved since the introduction of the deferiprone / deferoxamine ICOC protocol. The new epidemiological and other data suggest that in Cyprus, thalassaemia has changed from a fatal to a chronic disease.

The thalassaemia patients in Cyprus are active professionals, many have families and some are now becoming grandparents. New emerging medical challenges for many thalassaemia patients are the increasing immunological reactions to red blood cell transfusions and third age diseases.

Similarly, the control of births of patients with Friedreich Ataxia is almost identical to that of thalassaemia and involves the screening for carriers (heterozygotes) among premarital couples and providing prenatal diagnosis. Chelation therapy using deferiprone is currently the most promising therapy for Friedreich Ataxia, which is an untreatable inherited disease.

As in previous conferences the scientific programme will be complemented with many social activities, entertainment and excursions. The local organising committee hope that all participants will have stimulating scientific sessions, memorable experience and an enjoyable and relaxing time in Cyprus.

Dr Annita Kolnagou MD

Director of the Thalassaemia Unit, Paphos General Hospital and Postgraduate Research Institute, Paphos, Cyprus.

THE PRESIDENT OF INTERNATIONAL SOCIETY OF CHELATORS AND METALS (ISOCAM)

The island of Cyprus remains a highly attractive, convenient and friendly international location for hosting conferences, particularly in the warm mediterranean sunshine!

For over 25 years, the organizing committees have excelled in preparing this interesting series of meetings, and as President of the International Society of Chelators and Metals (ISOCAM), I would like welcome all delegates and friends to Cyprus to join the 27th ICOC -9th RAHMS -6th ICOAR Conference.

This conference has a strong and long history of covering broad and interesting topics including thalassaemia, iron overload disease, iron metabolism, iron chelation particularly in iron overload conditions, but also a range of related general areas that are currently topical. In fact, iron and copper chelation is now being considered more widely in patient treatment with several agents in multi-centre clinical trials for the treatment of cancer. As such, the conference also actively discusses other areas of interest including cancer, drug design and development, aging, reactive oxygen species generation, inflammation, neuro-degenerative and cardio-degenerative diseases, etc.

The organising committees ensure that the conference is highlighted ample discussion in round table sessions and also in sessions with patients particularly those with problems related to iron overload conditions such as β-thalassaemia major and also in cancer. The general aim of the conference is to stimulate new ideas and advances and to support international collaboration between scientists that will hopefully improve the treatment of a wide variety of patients.

Once again, the International Organising and Scientific Committees have intensively developed an interesting selection of research topics that should result in a memorable and stimulating conference in the very pleasant and sunny surroundings of Cyprus in summer! We look forward to seeing you in June!

Dr Des R. Richardson Ph D

Professor of Cancer Cell Biology
National Health and Medical Research Council of Australia (NHMRC)
Senior Principal Research Fellow, Department of Pathology and Bosch Institute,
University of Sydney, Sydney, New South Wales, Australia

THE PRESIDENT OF THE NINTH RECENT ADVANCES IN HEALTH AND MEDICAL SCIENCE
- SECTION OF TRADITIONAL CHINESE MEDICINE-

I welcome all of you to attend the Ninth International Conference on Recent Advances in Health and Medical Sciences (9th RAHMS) in Paphos, Cyprus. We joined this conference since the first RAHMS, and introduced the newly developing trends in Traditional Chinese Medicine (TCM), mainly about acupuncture and Chinese medicine progress every year.

Last year, we reported that the Low level laser therapy (LLLT) may lessen the pain on different laser wavelengths. In 2018 we will discuss about the laser and electric acupuncture treatments on the plantar incision model. Our results show beneficial effects of LLLT acupuncture therapy as a good additional therapy in reducing acute pain comparing the baseline and the end-point of the treatment.

It is my pleasure to invite all the guests in the 9th International Conference on Recent Advances in Health and Medical Sciences which take place in this beautiful sightseeing place in Paphos, Cyprus. I wish all of you will have a nice and pleasant time in Cyprus.

Dr Sheng-Feng Hsu MD

Asssociate Professor, Director, Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan.

THE PRESIDENT OF THE NINTH RECENT ADVANCES IN HEALTH AND MEDICAL SCIENCE
- SECTION OF NUTRITION AND OXIDATIVE STRESS -

I have attended two RAHMs conferences in Cyprus in previous years and I was enriched by the fruitful discussions at the conferences, fascinated by the beautiful countryside of Cyprus and amazed by the hospitality of the organizers.

This year's conference program expanded from oxidative stress to other areas of biomedical research, such as biomodulating activities of some natural nutrients, like extracts of polyphenolic compounds from natural sources, omega-3 fatty acids from fish oil or probiotics. Biological effects of natural nutrients can modulate different signaling pathways including oxidative stress. Oxidative stress is a phenomenon involved in a variety of biological or pathophysiological processes such as atherosclerosis, inflammation, ischemia-reperfusion injury, diabetes mellitus, neurodegenerative diseases, cancer, inflammation or aging, as well as rare diseases such as thalassaemia or disturbance in the metabolism of metals. The precise mechanisms of the involvement of reactive oxygen and nitrogen species in pathology of diseases are not always established. New data show that oxidative stress is not always toxic. Low oxidative stress is able to promote cellular proliferation rather than causing toxic effects and death of cells evoked by strong oxidative stress. Unfortunately, the border between low and strong oxidative stress is still not known.

Against the harmful effects of oxidative stress the organism has built protective systems which are significantly affected by lifestyle, nutritional habits and consumption of nutritive antioxidants present in fruits and vegetables. Oxidative stress in human is inextricably linked to lifestyle, psychic stress, nutrition habits, overweight and exercise habits.

The RAHM conference will open up possibilities for a discussion about the role of natural nutrients in diseases, such as depressive disorder, chronic fatigue, hepatitis and overweight. A protective role of probiotics will also be discussed.

We expect that the meeting will provide a challenging forum and pleasant environment for debates on results of own research in the context of information from internationally well known scientists.

On behalf of all organizers I would like to welcome you to Cyprus and I hope that the RAHMS and related meetings will enable us to make new contacts and collaborations. We hope that the presentations during the conference together with fruitful discussions of the participating experts will shift the level of our knowledge and will initiate progressive ideas for new projects in the field of biomodulating nutrients and oxidative stress in pathophysiology of different diseases.

Prof. Zdenka Ďuračková, PhD.,

Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Comenius University, Faculty of Medicine, Bratislava, Slovakia

WELCOME MESSAGE FROM THE CHAIRMAN OF
27th ICOC, 9th RAHMS and 6th ICOAR CONFERENCES

On behalf of the Local, International Organising and Scientific Committees, as well as other collaborating and participating organisations, I would like to welcome you to the 27th International Concference on Chelation (ICOC) for the treatment of Thalassaemia, Cancer and other Diseases of metal and free radical imbalance and toxicity, the 9th International Conference on Recent Advances in Health and Medical Sciences (RAHMS), and the 6th International Conference on Oncology and Anticancer Rersearch (ICOAR), which will take place in Paphos, Cyprus, 22-27th of June, 2018.

This year the ICOC conference will discuss the breakthrough in iron chelation therapy namely the complete treatment of transfusional iron overload with Deferiprone and Deferiprone / Deferoxamine combination but also the initiation of the application of chelation in many diseases. The development of chelating drugs is rapidly advancing with possible use in the treatment of many metal toxicities but also cancer, malaria, microbial, renal, neurodegenerative and many other diseases such as those linked to free radical pathology which includes almost all diseases of tissue damage and ageing. The impact of nutrition, environmental factors, traditional Chinese medicine in health and disease will also be discussed during the conferences.

The ICOC/ RAHMS/ ICOAR joint conferences is an open platform conferences used for stimulating research and open discussions in a many scientific and academic areas from chemistry to medicine. It is one of the few academic conferences with publications of its proceedings in international journals. The conference addresses the latest developments in health and medical sciences and also ethical issues, orphan diseases, controversies eg the mega Novartis scandal in Greece, commercial interference in academia and medicine, patient rights etc, all of which are essential for world health. Distinguished colleagues, scientists, medical practitioners, health professionals and students from all over the world will gather to present and discuss their scientific findings and also of other issues related to science and health.

The role of academia in health, drug design and development, medical and scientific publishing etc and the need to institute organisations for the management of such activities by academics for the benefit of academics, patients and the public at large will also be discussed. In this context, the global perspective of health, disease and environmental issues, require international cooperation to make the design, development and implementation of international health policies possible.

As in previous conferences, we will be organising many social and other events and also a constructive, high standard scientific and medical meeting in Cyprus.

Dr George J Kontoghiorghes Ph D

Professor, Director, Postgraduate Research Institute of Science, Technology, Environment and Medicine, Limassol, Cyprus.